Environmentally-friendly preparation of chitosan microspheres and encapsulation studies of cinnamaldehyde: Тowards convenient sustained release system for cinnamaldehyde

Authors

  • Elif Karacan Yeldir Canakkale Onsekiz Mart University
  • Ayhan Oral Canakkale Onsekiz Mart University

DOI:

https://doi.org/10.20450/mjcce.2021.2407

Keywords:

chitosan, cinnamaldehyde, sustained release, microspheres

Abstract

Chitosan, a biodegradable and biocompatible polysaccharide, is a biopolymer with high potential for biomedical applications. In the scope of this study, chitosan microcapsules were prepared via a green method, without using any surfactants or crosslinkers. Cinnamaldehyde encapsulated microspheres were obtained by the same method and characterized by FTIR spectroscopy, XRD spectroscopy, and SEM. The release study of encapsulated cinnamaldehyde was carried out in a pH 7.4 phosphate buffered saline (PBS) at 37 °C. The amount of cinnamaldehyde released was analyzed using UV-Vis spectroscopy and GC/MS-MS. Accordingly, it was found that 350 mg of cinnamaldehyde was encapsulated per gram of chitosan, and the maximum amount of cinnamaldehyde released into the PBS medium was about 8 ppm. In addition, the release was seen to continue when the buffer was renewed. It is thought that the obtained cinnamaldehyde encapsulated chitosan microspheres could be used as a sustained release system.

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Published

2021-12-01

How to Cite

Karacan Yeldir, E., & Oral, A. (2021). Environmentally-friendly preparation of chitosan microspheres and encapsulation studies of cinnamaldehyde: Тowards convenient sustained release system for cinnamaldehyde. Macedonian Journal of Chemistry and Chemical Engineering, 40(2), 253–261. https://doi.org/10.20450/mjcce.2021.2407

Issue

Vol. 40 No. 2 (2021)

Section

Polymers

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