Zinc complex based determination of rutin in dietary supplements

Authors

  • Leposava Pavun University of Belgrade-Faculty of Pharmacy
  • Milena Jelikić Stankov University of Belgrade-Faculty of Pharmacy
  • Predrag Đurđević Faculty of Science, University of Kragujevac
  • Andrija Ćirić Faculty of Science, University of Kragujevac
  • Snezana Uskokovic-Markovic University of Belgrade-Faculty of Pharmacy

DOI:

https://doi.org/10.20450/mjcce.2016.897

Keywords:

flavonoids, rutin, zinc complex, spectrophotometric determination

Abstract

The aim of this study was to develop and validate a simple, rapid and sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in 70 v/v% methanol at pH 8.52, and λmax= 410 nm. Linearity range was defined as 0.3- 12.2 mg mL-1, LOD = 0.21 mg mL-1 and LOQ = 0.63 mg mL-1. The proposed method was successfully applied for determination of rutin in herbal based dietary supplements. The reliability of the method was checked by comparison with results obtained by RP-HPLC/UV method. The proposed method fulfills all aimed requirements.

Author Biography

Snezana Uskokovic-Markovic, University of Belgrade-Faculty of Pharmacy

Department of Analytical Chemistry

References

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Published

2016-04-18

How to Cite

Pavun, L., Jelikić Stankov, M., Đurđević, P., Ćirić, A., & Uskokovic-Markovic, S. (2016). Zinc complex based determination of rutin in dietary supplements. Macedonian Journal of Chemistry and Chemical Engineering, 35(1), 13–18. https://doi.org/10.20450/mjcce.2016.897

Issue

Section

Analytical Chemistry

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